基本信息

姓名：张文

学位：博士

导师情况：硕导

研究方向：消化系统损伤修复机制与防治技术

电子邮箱：wenzhang@tjcu.edu.cn

个人简介

张文，1990年生，于天津大学化工学院获博士学位，现任天津商业大学副教授，硕导，天商青年学者，《食品研究与开发》杂志青年编委，从事消化系统损伤修复机制与防治技术研究，取得特色成果。主持国家自然科学基金项目，参与国家级或省部级科研项目4项，在国际一流期刊Nucleic Acids Res、Military Med Res、Cell Death Dis等发表论文20余篇，其中SCI一区论文10篇（累计IF＞100，单篇最高IF达34），授权国家发明专利3项。

招生方向

生物与医药（生物技术与工程 专硕）、轻工技术与工程（学硕）

主持的代表性科研项目

1、国家自然科学基金青年科学基金项目，BRISC复合体在肝再生中的调控作用及机制研究，2023.01-2025.12，主持；

2、 天津商业大学新进教师科研启动项目，硫藤黄菌素纳米颗粒改善消化系统损伤的功能研究，2022.01-2025.12，主持；

3、 天津市科技计划项目，策勒县红枣核桃深加工关键技术研发，2022.09-2024.09，参与；

4、 天津市科技计划项目，应用基础研究，基于毛细管理论解析黄原胶抑制多酚-蛋白互作改善肌原纤维蛋白凝胶持水性的机制，2022.10 至-2024.09，参与；

5、 北京市自然科学基金面上项目，ABRO1敲除小鼠抵抗蛋氨酸-胆碱缺乏饲料诱导的非酒精性脂肪肝病及机制研究，2019.01-2021.12，参与；

6、国家自然科学基金面上项目，缺失ABRO1抑制kupffer细胞TLR4信号通路保护LPS/D-Gal诱导的急性肝衰竭的机制研究，2019.01-2022.12，参与。

代表性学术论文

[1]. Xinyi Lv, Zijian Wu*, Limin Wang, Peibo Guo, Ao Qu, Wenjing Liang, Pengbo Zheng, Yuan Li, Wen Zhang*. The curcumin-loaded zein-shellac nanoparticles using pH-driven method: Fabrication, characterization, and anti-inflammatory effect. Journal of Functional Foods, 2025,125: 106692. (二区Top，通讯作者)

[2]. Wenjing Lian, Wen Zhang*, Jiayi Tian, Xinping Zhang, Xinyi Lv, Ao Qu, Jinyu Chen, Zijian Wu*. Advances in carbohydrate-based nanoparticles for targeted therapy of inflammatory bowel diseases: A review. International Journal of Biological Macromolecules, 2024, 281:136392. (一区Top，通讯作者)

[3]. Xinping Zhang, Zijian Wu*, Wen Zhang*, Limin Wang, Pei Zhao, Xinyi Lv, Peibo Guo, Jinyu Chen. Surface modification by chitosan for improving stability and antioxidative activity of astaxanthin-loaded liposomes. LWT-Food Science and Technology, 2024, 198: 116033. (一区Top，通讯作者)

[4]. Wen Zhang#, Kai Liu#, Guangming Ren, Yu Wang, Ting Wang, Xian Liu, Dongxu Li, Yang Xiao, Xu Chen, Yating Li, Yiqun Zhan, Shensi Xiang, Hui Chen, Huiying Gao, Ke Zhao, Miao Yu, Changhui Ge, Changyan Li, Zhiqiang Ge, Xiaoming Yang* and Ronghua Yin*. BRISC is required for optimal activation of NF-κB in Kupffer cells induced by LPS and contributes to acute liver injury. Cell Death Dis, 2023, 14(11):743. (一区Top，第一作者)

[5]. Wen Zhang#, *, Lingli Meng#, Xinyi Lv, Limin Wang, Pei Zhao, Jinrong Wang, Xinping Zhang, Jinyu Chen, ZijianWu*. Enhancing Stability and Antioxidant Activity of Resveratrol-Loaded Emulsions by Ovalbumin–Dextran Conjugates. Foods, 2024, 13: 1246. (二区，第一作者)

[6]. Wen Zhang#, Guijun Zhang#, Wenjing Liang, Jiayi Tian, Shuhao Sun, Xinping Zhang, Xinyi Lv, Peibo Guo, Ao Qu and Zijian Wu*. Structure, Functional Properties, and Applications of Foxtail Millet Prolamin: A Review. Biomolecules. 2024, 14(8): 913. (二区，第一作者)

[7]. Wen Zhang, Lei Wang, Xuehua Sun, Xian Liu, Yang Xiao, Jie Zhang, Ting Wang, Hui Chen, Yiqun Zhan, Miao Yu, Changhui Ge, Changyan Li, Guangming Ren*, Ronghua Yin*, Xiaoming Yang*. Toll-like receptor 5-mediated signaling enhances liver regeneration in mice. Military Medical Research, 2021, 8(1):16. (一区Top，第一作者)

[8]. Mingfei Han#, Xian Liu#, Wen Zhang#, Mengnan Wang, Wenjing Bu, Cheng Chang, Miao Yu, Yingxing Li, Chunyan Tian, Xiaoming Yang*, Yunping Zhu*, Fuchu He*. TSMiner: a novel framework for generating time-specific gene regulatory networks from time-series expression profiles. Nucleic Acids Research, 2021, 49(18): e108. (一区Top，共同第一作者)

[9]. Ting Wang#, Wen Zhang#, Xian Liu, Guangming Ren, Shensi Xiang, Yiqun Zhan, Hui Chen, Huiying Gao, Ke Zhao, Miao Yu, Changyan Li, Xiaoming Yang* and Ronghua Yin*. BRISC inactivation alleviates alcohol-induced liver injury in mice. Scientific Reports. 2025, 15(1):5154. (二区，共同第一作者)

[10]. Wen Zhang*, Xinping Zhang, Xinyi Lv, Ao Qu, Wenjing Liang, Limin Wang, Pei Zhao and ZijianWu*. Oral delivery of astaxanthin via carboxymethyl chitosan-modified nanoparticles for ulcerative colitis treatment. Molecules, 2024, 29(6):1291. (二区，第一作者)

[11]. Peibo Guo#, Wen Zhang#, Pei Zhao*, Xinyi Lv, Ao Qu, Wenjing Liang, Huijing Hou, Ying Li, Zijian Wu*. Isobavachalcone-loaded electrospun polycaprolactone/gelatin nanofibers for antibacterial and antioxidant applications. Biomed Mater. 2025 Feb 28;20(2). (三区，共同第一作者)

[12]. Wen Zhang, Shousong Tao, Ting Wang, Jie Zhang, Xian Liu, Yating Li, Hui Chen, Yiqun Zhan, Miao Yu, Changhui Ge, Changyan Li, Guangming Ren*, Xiaoming Yang*, Ronghua Yin*. ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2. FEBS Letters, 2021, 595(2): 169-182. (二区，第一作者)

[13]. Wen Zhang, Shousong Tao, Ting Wang, Yating Li, Hui Chen, Yiqun Zhan, Miao Yu, Changhui Ge, Changyan Li, Guangming Ren*, Ronghua Yin*, Xiaoming Yang*. NLRP3 is dispensable for d-galactosamine/lipopolysaccharide-induced acute liver failure. Biochemical and Biophysical Research Communications, 2020, 533(4): 1184-1190. (三区，第一作者)

代表性专利

1、硫藤黄菌素在抑制NLRP3炎症小体活化中的应用；中国；ZL 2018 1 0054935.6 (授权)

2、全霉素在抑制NLRP3炎症小体活化中的应用；中国；ZL 2018 1 0928906.8 (授权)

3、硫藤黄菌素在保护非酒精性脂肪性肝炎中的应用；中国；ZL 2021 1 0265792.5 (授权)

4、一种负载姜黄素的玉米醇溶蛋白-天然胶纳米复合物的制备方法；中国；202411000722.7（申请）

5、一种抗菌抗氧化纳米纤维敷料及其制备方法；中国；202411000856.9（申请）